Norovirus Gastroenteritis

Norovirus gastroenteritis in immunocompromised patients.

Copyright © 2012 Massachusetts Medical Society. Infectious gastroenteritis is a common, acute illness that is characteristically self-limiting, but it can become debilitating and life-threatening in immunocompromised patients.1 Noroviruses are major pathogens among the microbes associated with gastroenteritis in both immunocompetent and immunocompromised hosts1-4 (Table 1). In the United States...

Norovirus Gastroenteritis, Carbohydrate Receptors, and Animal Models

Noroviruses, an important cause of acute gastroenteritis in humans, have been found to recognize the histo-blood group antigens (HBGAs) as receptors. Different noroviruses revealed different receptor-binding profiles associated with the ABO, secretor, and Lewis HBGA types. Direct evidence of HBGA receptor recognition in viral infection and tropism was obtained from human volunteer challenge stu...

Norovirus in benign convulsions with mild gastroenteritis

BACKGROUND Benign convulsions with gastroenteritis (CwG) are defined as afebrile convulsions accompanying symptoms of gastroenteritis without evidence of laboratory derangement. Although the main pathogen has been known as rotavirus, since the introduction of rotavirus vaccine, associated viruses with CwG may have changed. Thus, we evaluated the viral association of CwG for patients admitting f...

Norovirus gastroenteritis in US Marines in Iraq.

Fecal Viral Load and Norovirus-associated Gastroenteritis

We report the median cDNA viral load of norovirus genogroup II is >100-fold higher than that of genogroup I in the fecal specimens of patients with norovirus-associated gastroenteritis. We speculate that increased cDNA viral load accounts for the higher transmissibility of genogroup II strains through the fecal-oral route.